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Controlled release system for localized and sustained drug delivery applications
Table of Contents
Abstract
Acknowledgements
Table of Contents
List of Tables
List of Figures
List of Abbreviations
1 Introduction
1.1 Motivation
2 Literature Review
2.1 Polymeric drug delivery systems
2.2 Considerations for selection of polymers
2.3 Biodegradable polymers for drug delivery systems
2.4 Chitosan
2.3.1 Degradation of chitosan
2.3.2 Applications of chitosan
2.5 Selection of the model drug .
3 Experimental Methods
3.1 Fourier Transform Infrared (FTIR) Spectrometry
3.2 UV/Vis Spectrometry
3.3 Scanning Electron Microscopy Analysis (SEM) and Energy Dispersive X-ray Spectroscopy (EDS
3.4 Liquid chromatography mass spectrometry
3.4.1 Analysis of ASA
3.4.2 Analysis of D, L –AP5
3.5 Inductively coupled plasma optical emission spectrometry (ICP-OES)
3.6 Atomic Force Microscopy (AFM)
4 Preparation of particles by the coacervation technique
4.1 Introduction
4.2 Materials and Methods
4.2.1 Materials
4.2.2 Preparation of chitosan particles
4.2.3 Characterization of chitosan particles
4.2.4 Swelling studies of chitosan particles
4.2.5 Adsorption of ASA on cross-linked particles
4.2.6 Drug release studies
4.2.7 Coating of chitosan particles
4.3 Results and Discussion
4.3.1 Morphology of chitosan particles
4.3.2 Chemical characterization of chitosan particles
4.3.3 Swelling studies of chitosan particles
4.3.4 Adsorption of ASA on cross-linked particles
4.3.5 In vitro ASA release study
4.3.6 Coating of chitosan particles
4.3.7 Characterization of coated particles
4.4 Summary
5 Preparation of particles by emulsion cross-linking technique
5.1 Introduction
5.2 Materials and methods
5.2.1 Materials
5.2.2 Emulsion cross-linking technique
5.2.3 Optimization of the emulsion cross-linking technique
5.2.4 Characterization of chitosan microparticles
5.2.5 Evaluation of “P” leaching
5.2.6 Determination of drug loading efficiency
5.2.7 In vitro release studies
5.3 Results
5.3.1 Microparticles preparation using emulsion cross-linking technique
5.3.2 Characterization of chitosan microparticles
5.3.3 Effect of agitation speed
5.3.4 Effect of TPP
5.3.5 Effect of chitosan
5.3.6 Mean particle size and particle size distribution
5.3.7 Drug loading efficiency
5.3.8 Evaluation of “P” leaching
5.3.9 In vitro release of ASA
5.4 Discussions
5.4.1 Effect of agitation speed
5.4.2 Effect of TPP
5.4.3 Effect of chitosan
5.4.4 Drug loading efficiency
5.4.5 In vitro release of ASA
5.4.6 Effect of the formulation variables
5.5 Summary
6 Evaluation of chitosan microparticles loaded with other compounds
6.1 Introduction
6.1.1 Hydrophilic compounds
6.1.2 Lipophilic compounds
6.2 Materials and methods
6.2.1 Materials
6.2.2 Synthesis of chitosan microparticles
6.2.3 Microparticles morphology
6.2.4 Drug loading efficiency
6.2.5 In vitro release studies
6.3 Results and Discussion
6.3.1 Microparticle morphology
6.3.2 Drug loading efficiency
6.3.3 In vitro release studies
6.4 Summary
7 Synthesis of coated chitosan microparticles
7.1 Introduction
7.1.1 Poly lactic acid (PLA)
7.1.2 Poly lactic‐co‐glycolic acid (PLGA)
7.1.3 Biocompatibility and Biodegradability of PLA and PLGA
7.2 Materials and Methods
7.2.1 Materials
7.2.2 Preparation of coated chitosan microparticles
7.2.3 Morphology of coated chitosan microparticles
7.2.4 FTIR analysis
7.2.5 Swelling study
7.2.6 In vitro release of ASA
7.3 Results and Discussion
7.3.1 FTIR analysis
7.3.2 Swelling study
7.3.3 Morphology of coated chitosan microparticles
7.3.4 In vitro release of ASA
7.4 Summary
8 Degradation of chitosan microparticles
8.1 Materials and Methods
8.1.1 Materials
8.1.2 In vitro degradation without enzyme
8.1.3 In vitro degradation with enzyme
8.1.4 Characterization of degraded chitosan microparticles
8.2 Results and Discussion
8.2.1 Evaluation of degradation without enzyme
8.2.2 Evaluation of degradation with enzyme
8.2.3 FTIR analysis
8.2.4 Morphology of degraded chitosan microparticles
8.3 Summary
9 Conclusions
10 Future Work
References Bài viết liên quan
