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Development of an intervertebral cage using additive manufacturing with embedded NiTi hinges for a minimally invasive deployment


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Development of an intervertebral cage using additive manufacturing with embedded NiTi hinges for a minimally invasive deployment
Contents
Abstract
Acknowledgments
Contents
List of Tables
List of Figures
List of Abbreviations
List of Symbols
1 Introduction
1.1 Problem Statement
1.2 Objective
1.3 Approach
1.4 Contribution
1.5 Outline
2 Background
2.1 State of the art for spinal fusion
2.1.1 ALIF
2.1.2 PLIF
2.1.3 TLIF
2.1.4 LLIF
2.2 Medical trends
2.3 Nitinol
2.3.1 Nitinol modeling
2.3.2 Nitinol applications
2.4 Biocompatibility of nitinol
2.5 Additive Manufacturing
2.5.1 Electron Beam Melting
2.5.2 Selective Laser Melting
2.6 Summary
3 Modeling and experimental evaluation of nitinol
3.1 Lagoudas model for nitinol
3.2 Experiments
3.3 Modeling Results & Discussion
3.3.1 Rod
3.3.2 Tube
3.4 MATLAB (non-Mises) modeling
3.5 Design of the nitinol hinge elements .
3.6 Summary
4 Design of the EndoFuzec cage
4.1 Generation 2 & 3 design
4.1.1 Cage geometry and lordosis accommodation
4.1.2 Manufacturing
4.1.3 Hinge actuation concept .
4.1.4 Cage delivery concept
4.2 Summary
5 Results
5.1 ASTM specication for testing spinal implants
5.2 Generation 1 experimental results
5.3 Experimental evaluation of the generation 2 EndoFuze cage
5.4 Finite element analysis of the generation 3 cage
5.5 Summary
6 Business plan
6.1 Executive Summary
6.2 Opportunity Rationale
6.3 The Company
6.4 The Product
6.5 Industry Overview
6.5.1 EndoFuze Five Forces analysis and positioning
6.5.1.1 Five Forces Analysis
6.5.1.2 EndoFuze positioning
6.6 Market Size and Trends
6.7 Estimated Market Share and Sales
6.8 Competition
6.8.1 Ongoing Market Evaluation
6.9 Regulatory Issues
6.10 Management Team and Organizational Structure
6.11 Marketing Plan
6.11.1 Market Entry and Growth Strategy
6.11.2 Advertising and Promotion
6.11.3 Price
6.11.4 Sales Strategy
6.11.5 Distribution
6.11.6 Service and Warranty Policies
6.12 Patents and Proprietary Issues
6.13 Product Design and Development Plans
6.14 Manufacturing and Operations Plan
6.15 Financial Plan
6.15.1 Detailed Breakeven Analysis
6.15.2 Quarterly ProForma Cash Flow Statements over a 5 year period
6.15.3 Quarterly ProForma Income Statements over a 5 year period .
6.16 Critical Risks and Contingency Plans
7 Conclusions
References 
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