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Heme oxygenase system in myocardial infaction and cardio-renal syndrome
TABLE OF CONTENTS
ABBREVIATIONS
ABSTRACT
1. INTRODUCTION
2. REVIEW OF THE LITERATURE
2.1. History of Heme Oxygenase-1 (HO)
2.2. Induction and regulation of HO-1
2.2 A. HO-1-inducing factors
2.2. B. Regulation of HO-1 expression
2.3. Protective role of HO-1 and its reaction products
2.3. A Antioxidant effect
2.3. B Antiproliferative effect
2.3. C Anti-inflammatory effect
2.3. D. Antiapoptotic effect
2.3. E. Vasoactive effects
2.3. F.Proangiogenic effect
2.4. HO-1 and its reaction product in cardiovascular disease
2.4. A.HO-1 in myocardial infarction and heart failure
2.4. B. HO-1 in Atherosclerosis
2.4. C. HO-1 in Hypertension
2.5. Renal injury and HO-1
2.6. RISK Pathway
2.6. A. AKT pathway
2.7. Myocardial energy metabolism
3. AIMS OF THE STUDY
4. MATERIALS AND METHODS
4.1. Animals
4.2. Experimental Myocardial Infarction (LAD method)
4.3. Echocardiographic evaluation
4.4. Renal echo-Doppler
4.5. Drug administration
4.6. Renal histology
4.7. Plasma Renin and Plasma Angiotensin-II estimation
4.8. ELISA-inflammatory cytokines
4.9. Plasma Creatinine estimation
4.10. Protein Extraction and Western blot
4.11. Statistical analysis
5. RESULTS
5.1. Effect of CoPP administration on cardiac function
5.2. Effect of CoPP administration on cardiac HO-1 expression
5.3. Effect of CoPP administration on cardiac angiogenesis
5.4. Effect of CoPP administration on cardiac energy metabolism
5.5. Effect of CoPP administration on myocardial protection
5.6. Effect of CoPP administration on myocardial oxidative damage
5.7. Effect of CoPP administration on renal arterial resistance
5.8. Effect of CoPP administration on post myocardial renal function
5.9. Effect of CoPP administration on renal fibrosis
5.10. Effect of CoPP administration on renin angiotensin system
5.11 Effect of CoPP administration on systemic inflammation
6. Discussion
7. Future prospects
8. ReferencesBài viết liên quan
