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Natural products-inspired synthesis and biological evaluation of bioactive agents
Table of Contents
Abstract
Acknowledgements
Table of Contents
List of Tables
List of Figures
List of Schemes
List of Spectra
List of Abbreviations
1 Neuroprotective Agents: Introduction
2 Neuroprotective Agents: Results and Discussion
2.1 Synthesis of 12-17
2.2 Biological Studies Results
2.3 Discussion
3 Neuroprotective Agents: Experimental Section
3.1 Synthesis
3.2 Biological Evaluation
4 Largazole Analogues: Introduction
4.1 HDAC Isoforms and Current HDAC Inhibitors
4.1.1 Class I HDAC Complexes
4.1.2 CLASS II HDACs
4.2 HDAC Inhibitors
4.3 Largazole SAR
4.4 Mechanism of HDAC Inhibitor-Induced Cell Death
4.5 Drug Design and Rationale
5 Largazole Analogues: Results and Discussion
5.1 Retrosynthetic Analysis of Largazole Analogues JA1-JA6
5.2 Synthesis of Acetyl Nagao Auxillary 48
5.3 Synthesis of Alcohol 53
5.4 Synthesis of Analogue JA1
5.5 Synthesis of Bi-Pyridine Analogue JA2
5.6 Synthesis of Fragments 43-46
5.7 Synthesis of Analogues JA3-JA6
6 Largazole Analogues: Biological Studies
6.1 Results and Discussion
6.2 Discussion
7 Largazole Analogues: Future Directions
8 Largazole Analogues: Experimental Section
8.1 Synthesis
8.2 Biological Evaluation
References
Appendix A: (1H and 13C NMR Spectra) Bài viết liên quan
