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Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans
Table of Contents
Abstract
Acknowledgements
Table of Contents
List of Figures
List of Abbreviations
List of Symbols
1 Introduction
1.1 Monoamines and neuropeptides as co-modulators for global signaling cascades in mammals and invertebrates
1.2 The role of TA as a neuromodulator in mammals and invertebrates
1.3 Significance
2 Materials and Methods
2.1 Materials
2.2 Nematode growth and strains
2.3 Behavioral assays
2.4 Molecular biology and transgenesis
2.5 Generation of neuron-selective RNAi constructs
2.6 cDNA cloning and sequencing
2.7 Phosphoinositide turnover and cAMP levels
2.8 Microscopy and image analysis
3 Results
3.1 The Gαq-coupled TA receptor, TYRA-3, is essential for the TA inhibition of 5-HT-stimulated aversive responses to dilute 1-octanol
3.2 TYRA-3 functions in dopaminergic, octopaminergic and peptidergic neurons to inhibit the food or 5-HT-stimulation of aversive responses to dilute 1-octanol.
3.3 TYRA-3 stimulates the release of multiple inhibitory peptides from the ASIs.
3.4 Both Gαq and Gαs signaling in the ASIs are required for TA inhibition
3.5 Peptides encoded by nlp-1 and nlp-14 activate NPR-11 and NPR-10, respectively, to mediate TA/TYRA-3-dependent inhibition.
4 Discussion
4.1 Small changes in TYRA-3 signaling may have dramatic effects on locomotory behavior
4.2 TYRA-3 signaling may stimulate the release of both OA and DA to inhibit ASH-mediated aversive behavior.
4.3 TA and OA stimulate the release of distinct and non-overlapping pools of neuropeptides from the ASIs to inhibit ASH-mediated aversive behaviors.
4.4 The role of TA in locomotory-decision making: understanding the circuits modulating spontaneous and sensory-evoked reversal
4.5 The neuropeptides involved in the TA or OA inhibition of aversive responses may be packaged into different large dense-core vesicles in the ASIs.
4.6 Changes in nutritional status can also have long-term effects on olfaction and its associated behaviors
4.7 Summary
ReferencesBài viết liên quan
