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Preparation and evaluation of oil-in-water self-nanoemulsifying systems with potential for pulmonary delivery
Table of Contents
Abstract
Acknowledgements
Table of Contents
List of Tables
List of Figures
List of Abbreviations
1. Introduction
1.1 Lipid based drug delivery systems
1.2 Self-emulsifying/nanoemulsifying drug delivery systems (SEDDS/SNEDDS)
1.3 Theory of nanoemulsion formulation
1.4 Excipient selection
1.5 Drug incorporation
1.6 Pulmonary delivery
1.6.1 Mechanism of drug absorption through lungs
1.6.2 Pulmonary drug delivery devices
2. Instrumentation
2.1 Dynamic light scattering
2.1.1 Principle
2.1.2 Instrumentation
2.1.3 Sample preparation
2.1.4 Application
2.2 Electrophoretic light scattering
2.2.1 Principle
2.2.2 Instrumentation
2.2.3 Sample preparation
2.2.4 Application
2.3 Transmission electron microscopy
2.3.1 Principle
2.3.2 Instrumentation
2.3.3 Sample preparation
2.3.4 Application
2.4 Ultraviolet - Visible spectrophotometry
2.4.1 Principle
2.4.2 Instrumentation
2.4.3 Sample preparation
2.4.4 Application
2.5 Differential scanning calorimetry
2.5.1 Principle
2.5.2 Instrumentation
2.5.3 Sample preparation
2.5.4 Application
2.6 High performance liquid chromatography
2.6.1 Principle
2.6.2 Instrumentation
2.6.3 Sample preparation
2.6.4 Application
2.7 Fluorescence microscopy
2.7.1 Principle
2.7.2 Instrumentation
2.7.3 Sample preparation
2.7.4 Application
3. Materials and Methods
3.1 Materials
3.1.1 Cremophor RH 40
3.1.2 Tween 80
3.1.3 Labrasol
3.1.4 Polyethylene Glycol 400
3.1.5 Capryol 90
3.1.6 Transcutol P
3.1.7 Labrafil M 2125 CS
3.1.8 Carbamazepine
3.1.9 Sudan IV
3.2 Methods
3.2.1 Drug selection
3.2.2 Drug solubility determination
3.2.3 Selecting excipients for self-nanoemulsification
3.2.4 Evaluation of nanoemulsifying properties of SME mixtures
3.2.5 Drug loading of nanoemulsion
3.2.6 Droplet size and zeta potential measurements
3.2.7 Thermodynamic properties
3.2.8 Transmission electron microscopy of SNEDDS
3.2.9 Sterility testing
3.2.10 Cell toxicity analysis
3.2.11 Nebulization of nanoemulsions
3.2.12 Droplet size determination of the mist
3.2.13 Transmission electron microscopy of the mist
3.2.14 Histological analysis
3.2.14.1 Dye solubility determination
3.2.14.2 Dye incorporation of nanoemulsion
3.2.14.3 Droplet size and zeta potential of dye loaded nanoemulsions
3.2.14.4 Histological assay
4. Results and discussions
4.1 Drug solubility determination
4.2 Selection of excipients
4.3 Characterization of liquid SNEDDS
4.3.1 Droplet size determination
4.3.2 Zeta potential measurements
4.3.3 Thermodynamic properties
4.3.4 TEM images
4.4 Validation of sterility
4.5 Cell toxicity
4.6 Characterization of nebulized SNEDDS (mist)
4.6.1 Droplet size distribution of the mist
4.6.2 TEM images of the mist
4.7 Histological analysis
4.7.1 Dye solubility determination
4.7.2 Droplet size and zeta potential of dye loaded nanoemulsion
4.7.3 Microscopic examination of cryosections
5. Conclusions
ReferencesBài viết liên quan
