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The preparation and characterization of poloxamer-based temperature-sensitive hydrogels for topical drug delivery
List of content
Abstract
Acknowledgements
List of abbreviations
1. Introduction
1.1 What is a gel?
1.2 Hydrogels
1.3 Stimuli-sensitive hydrogel
1.4 temperature-sensitive poloxamer based hydrogel
1.5 Evaluation of temperature-sensitive hydrogels
1.5.1 Measurement of sol-gel transition temperature
1.5.2 Rheological properties
1.5.3 Mechanical properties
1.5.4 Mucoadhesive properties
1.5.5 Drug release properties
1.6 Pharmaceutical applications of temperature-sensitive poloxamer based hydrogels
1.6.1 Topical or local drug delivery
1.6.2 Parenteral drug delivery
1.7 Aim of thesis
References
2. Instrumentation
2.1UV/VIS Spectrophotometer
2.2 Rheometer
2.3 Texture profile analyzer
2.4 High performance liquid chromatography
References
3. Materials and Methods
3.1 Materials
3.1.1 Poloxamer 407 NF
3.1.2 Propylene glycol
3.1.3 Transcutol-P
3.1.4 Polyethylene glycol 400
3.1.5 Lauryl glycol
3.1.6 Capryol 90
3.1.7 Fluconazole
3.2 Methods
3.2.1 Solubility studies
3.2.2 Preparation of temperature sensitive hydrogels
3.2.3Measurement of sol-gel transition temperatures
3.2.3.1 Method A
3.2.3.2 Method B
3.2.4 Rheological and viscoelastic studies
3.2.5 Texture profile analysis (TPA)
3.2.6 Mucoadhesive studies
3.2.7 In-vitro drug permeability
3.2.8In-vitro antifungal activity test
3.2.9.1 Preparation of Mueller-Hinton agar supplemented with glucose and methylene blue (MHA-GMB) medium
3.2.9.2 Preparation of drug impregnated disks
3.2.9.3 Disk diffusion test
3.2.10 Statistical analysis
References
4. Results and discussion
4.1 Solubility analysis
4.2 Preparation of temperature sensitive hydrogels
4.3 Measurement of sol-gel transition temperature
4.4Rheological and viscoelactic properties
4.5 Texture profile analysis (TPA)
4.6 Mucoadhesive studies
4.7 In-vitro drug permeability
4.8 In-vitro antifungal activity
Conclusions
ReferencesBài viết liên quan
